ECCMID 2012: Coexistence of infection – NTDs, HIV and STDs

A recurring theme of the NTD sessions at this year’s ECCMID conference was the relationship between NTDs, HIV and STDs. Figures for each seem to overlap, as do some of the physical signs.

Geographical overlap of schistosomiasis and HIV infectionsEach complements the other’s existence. For example, an NTD’s (such as schistosomiasis) symptoms make target areas (in this case epithelium)  vulnerable and as a result ease the path of sexually transmitted disease (STDs) and HIV agents into the body. And with that, the person becomes coinfected by more than one dangerous illness.

The management of one, therefore, should take into account the others’. Here is a summary of what the ECCMID conference highlighted, particularly for schistosomiasis.

Continue reading

ECCMID 2012: Urogenital schistosomiasis

Dr Eyrun Kjetland from the School of Biological and Conservation Sciences at the University of KwaZulu-Natal in South Africa presented current research into urogenital schistosomiasis at this year’s ECCMID conference.

Taking a step back to begin with, she said schistosomiasis itself affects 2 billion people worldwide; 80 million of these show symptoms and just over 30 million receive treatment.

It’s a growing problem in some regions, particularly among travelers and migrants. People become infected with schistosomiasis when worm forms of the snail parasite penetrate their skin during contact with infested water. These then live in blood vessels where they grow and reproduce more schistosomes, or eggs. Eggs either pass through as waste or get trapped in the body, causing immune reactions and progressive damage to organs.

Kjetland described the current situation of one target of the schistosomes – the reproductive system. “In the last two decades,” she said, “after the first six community-based studies on this “gyneacological Schistosoma haematobium”, WHO has recommended that this form of the disease should be referred to as urogenital schistosomiasis.

Below is a summary of key points and issues Kjetland raised during her presentation.

Continue reading

3D sensor for the third D: diagnostic tools for infectious diseases

Last week we reported that the fight against neglected tropical diseases (NTDs) was many-fold – now an addition to the third D, diagnostics, literally lives up to that description. Chemists from the University of Texas at Austin have drawn inspiration from the art of origami to create a three-dimensional paper sensor that could test for diseases such as malaria and HIV for less than 10 pence.

The 3D oPAD sensor is less than 10p a pop

The 3D oPAD sensor is less than 10p a pop

Continue reading

The three D’s: new diagnostic tool for infectious diseases

The fight against neglected tropical diseases is many-fold but whilst there is much talk about drug development and delivery, another integral component of treating NTDs is the third D: diagnostics. It’s all very well having the drugs in the right place at the right time but if you don’t know who needs treating then they are no good.

A new technology unveiled last week could bring faster and more accurate results for detecting diseases in developing countries and is only half a centimetre long.

The readout system including the mini chips

Circuits: The readout system including the 5mm mini chips

Continue reading

Double blow for dengue

Nicaraguan children provided data for the study

Nicaraguan children provided data for the study

The reason dengue fever can be more severe a second time round is due to the genetic make-up of the virus, researchers at Berkeley have found. The results may help predict outbreaks of dengue and allow future treatments to be better targeted. Continue reading