Leishmaniasis funding from US Department of Defence in jeopardy

When you think of the people and organisations that usually fund NTD research, the US Department of Defence (DOD) isn’t the first one that springs to mind. Since the first Gulf War in the 1990s, the DOD has been trickling a small (relative to some of their other projects) but still significant amount of funding into leishmaniasis research.
Leishmaniasis is endemic in the Middle East, including Iraq and Afghanistan. In 2003, contracting leishmaniasis whilst on tour meant a one-way trip back to the US. In 2006, there were 1287 cases, with each soldier contracting leishmaniasis losing an average of 60 duty days.
DOD budgets show various amounts of funding for leishmaniasis projects, including one of a new skin treatment for the lesions the disease causes, and another for use of medical lasers to treat the lesions. In a report on the Gulf War, DOD spending on leishmaniasis between 1994 and 1998 adds up to just under $5m.The US Military has at times over the past century been at the forefront of reseach into dengue and typhoid fever, malaria, and HIV.
These are treatments that are developed for military personnel in war zones. They need to be transportable, effective in areas with only basic infrastructure and ideally without highly specialised medical personnel. And so, by saving money in defence, the US is simultaneously developing treatments and diagnostic tools that could be ideal for the elimination of the disease in civilians.
In 2008, the DOD accounted for 24% of all US federal spending on leishmaniasis. In 2012, that figure looks set to fall.  As Capitol Hill battles over spending, military research into diseases such as leishmaniasis could be cut, not only jeopardising soldier’s lives, but slowing the global war against NTDs.

Old antibiotic pill a new hope in fight against Yaws

Credit: CDC/Dr. Peter Perine

Credit: CDC/Dr. Peter Perine

A single antibiotic pill is just as effective a treatment as a shot of penicillin against yaws.  A study published in the Lancet that looked at 250 patients found oral azithromycin to be an equivalent treatment against the infection.  This could represent a major step in eradicating the disease because pills do not need a medical professional or equipment to be administered. Continue reading

Old drug new tricks: Fexinidazole sleeping sickness drug can also treat visceral leishmaniasis

A drug which has been used to target numerous infectious diseases has been successful in limiting the impact of visceral leishmaniasis (VL) too.

Fexinidazole has been used for over 30 years and studies are being conducted to ascertain its effect on sleeping sickness. The parasites that cause sleeping sickness and VL are closely related, so researchers at the University of Dundee decided to see whether the drug could also work against VL too.

VL is an infectious disease caused by a parasite that is transmitted by the bite of an infected sandfly. After malaria, it is the biggest killer in many parts of Africa, Asia and Latin America. Estimates put 50,000 killed every year but WHO say this is a huge underestimate as many cases are never recorded. 1.5-2 million new cases occur annually even though only around 600,000 are declared, the WHO have said.

If left untreated, VL can have a fatality rate as high as 100% within two years. Safer and more effective oral drugs are required to treat this parasitic disease as current drug treatments are expensive, lead to harmful side effects and mostly given by injection, which is unsuitable in poor rural areas where VL strikes.

Now, a study published in the journal Science Translational Medicine has shown that Fexinidazole may be the ideal candidate.

Continue reading

What pictures are good pictures?

Buruli ulcer has horrifying effects. The Mycobacterium ulcerans pathogen eats away skin and occasionally bone, causing huge, bloody lesions on the arms and legs.

Lymphatic filariasis is equally shocking, though less stomach churning. In women, long-term infection leaves sufferers legs swollen with fluid; in men, fluid often gathers in the testes, swelling them to many times their normal size. Continue reading